LPAR6, lysophosphatidic acid receptor 6, 10161

N. diseases: 47; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020678
Disease: Hypotrichosis
Hypotrichosis 		0.500 GeneticVariation disease LHGDN [Involvement of receptor P2Y5 and its ligand LPA in hypotrichosis simplex and autosomal recessive wooly hair syndrome]. 19061667 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.030 AlteredExpression disease BEFREE We report HCC-associated changes in LPAR1, 3, and 6 mRNA and protein expression, with significantly increased LPAR6 in HCC versus NL and NTL. 23182454 2013
CUI: C3502073
Disease: Woolly Hair, Autosomal Recessive
Woolly Hair, Autosomal Recessive 		0.070 GeneticVariation disease BEFREE We have recently identified mutations in both LPAR6/P2RY5 and LIPH that are associated with autosomal recessive woolly hair (ARWH). 22385360 2013
CUI: C1854310
Disease: Hypotrichosis simplex
Hypotrichosis simplex 		0.510 GeneticVariation disease BEFREE We and others have previously reported mutations in the P2RY5 gene and the LIPH gene as being causal factors of autosomal recessive hypotrichosis simplex with or without woolly hair. 19529952 2009
CUI: C1836672
Disease: Total Hypotrichosis, Mari type
Total Hypotrichosis, Mari type 		0.100 GeneticVariation disease BEFREE We and others have previously reported mutations in the P2RY5 gene and the LIPH gene as being causal factors of autosomal recessive hypotrichosis simplex with or without woolly hair. 19529952 2009
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 PosttranslationalModification group BEFREE We also show that homozygous inactivation of P2RY5 was antecedent to the loss of RB1 during tumor development, and that nucleotide substitutions in P2RY5 represent a cancer predisposing factor. 17702869 2007
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 PosttranslationalModification group BEFREE We also show that homozygous inactivation of P2RY5 was antecedent to the loss of RB1 during tumor development, and that nucleotide substitutions in P2RY5 represent a cancer predisposing factor. 17702869 2007
CUI: C0020678
Disease: Hypotrichosis
Hypotrichosis 		0.500 AlteredExpression disease BEFREE Using this technique with whole genome SNP data generated from low density mapping arrays, we previously identified two genes that underlie autosomal recessive woolly hair (ARWH/hypotrichosis; OMIM278150), specifically P2RY5 and Lipase H (LIPH). 19365138 2009
CUI: C4721530
Disease: Congenital hypotrichia
Congenital hypotrichia 		0.090 AlteredExpression disease BEFREE Using this technique with whole genome SNP data generated from low density mapping arrays, we previously identified two genes that underlie autosomal recessive woolly hair (ARWH/hypotrichosis; OMIM278150), specifically P2RY5 and Lipase H (LIPH). 19365138 2009
CUI: C3502073
Disease: Woolly Hair, Autosomal Recessive
Woolly Hair, Autosomal Recessive 		0.070 GeneticVariation disease BEFREE Using this technique with whole genome SNP data generated from low density mapping arrays, we previously identified two genes that underlie autosomal recessive woolly hair (ARWH/hypotrichosis; OMIM278150), specifically P2RY5 and Lipase H (LIPH). 19365138 2009
CUI: C0020678
Disease: Hypotrichosis
Hypotrichosis 		0.500 GeneticVariation disease BEFREE To search for pathogenic mutations in the human P2RY5 gene in Pakistani families with autosomal recessive hereditary hypotrichosis. 19292720 2009
CUI: C4721530
Disease: Congenital hypotrichia
Congenital hypotrichia 		0.090 GeneticVariation disease BEFREE To search for pathogenic mutations in the human P2RY5 gene in Pakistani families with autosomal recessive hereditary hypotrichosis. 19292720 2009
CUI: C0343073
Disease: Wooly hair
Wooly hair 		0.400 GermlineCausalMutation phenotype ORPHANET To identify mutations in LPAR6 and LIPH genes in 17 consanguineous Pakistani families showing features of hypotrichosis/woolly hair. 21426374 2011
CUI: C1863512
Disease: HYPERCHOLESTEROLEMIA, AUTOSOMAL RECESSIVE
HYPERCHOLESTEROLEMIA, AUTOSOMAL RECESSIVE 		0.010 Biomarker disease BEFREE Three genes, DSG4, LIPH, and LPAR6 (P2RY5), have been reported to underlie ARH. 20213768 2010
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.010 Biomarker group BEFREE This study sought to determine LPAR expression, including the newly identified LPAR6, in normal human liver (NL), hepatocellular carcinoma (HCC), and non-tumor liver tissue (NTL), and LPAR expression and function in human hepatoma cells in vitro. 23182454 2013
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.020 AlteredExpression disease BEFREE This study aimed to evaluate LPAR6 expression in BC patients and to explore its possible role in BC. 30694446 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 AlteredExpression disease BEFREE This study aimed to evaluate LPAR6 expression in BC patients and to explore its possible role in BC. 30694446 2019
CUI: C0020678
Disease: Hypotrichosis
Hypotrichosis 		0.500 GeneticVariation disease LHGDN These results show that LIPH is a second causative gene for ARWH/hypotrichosis, giving rise to a phenotype clinically indistinguishable from P2RY5 mutations. 18830268 2009
CUI: C4049711
Disease: Lepidic Predominant Adenocarcinoma
Lepidic Predominant Adenocarcinoma 		0.010 Biomarker disease BEFREE The present study further substantiated involvement of LPAR6-LPA signaling in the pathogenesis of hypotrichosis/woolly hair and provided additional insight into the molecular mechanism of hair development. 25119526 2014
CUI: C3502073
Disease: Woolly Hair, Autosomal Recessive
Woolly Hair, Autosomal Recessive 		0.070 Biomarker disease BEFREE The mutations in both LIPH and LPAR6/P2RY5 are responsible for autosomal recessive woolly hair with or without hypotrichosis (ARWH/HT). 29346610 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 AlteredExpression group BEFREE The anti-tumor drug 5-Aza significantly upregulated LPAR6 expression in vitro, and LPAR6 might act as a tumor suppressor in BC. 30694446 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.030 Biomarker disease BEFREE Survival analysis showed that LPAR6, C5, SSTR5, GPR68, and P2RY4 may be involved in the molecular mechanisms of emodin therapy for HCC. 31236404 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 Biomarker group BEFREE RNAi-mediated attenuation of LPAR6 impaired HCC tumorigenicity in tumor xenograft assays. 25589345 2015
CUI: C1836672
Disease: Total Hypotrichosis, Mari type
Total Hypotrichosis, Mari type 		0.100 Biomarker disease BEFREE Recently, three clinically similar autosomal recessive forms of hypotrichosis [localized autosomal recessive hypotrichosis (LAH)1], LAH2 and LAH3 have been mapped on chromosomes 18q12.1, 3q27.3, and 13q14.11-q21.32, respectively. 18445047 2008
CUI: C1854310
Disease: Hypotrichosis simplex
Hypotrichosis simplex 		0.510 GermlineCausalMutation disease ORPHANET Recently mutations in a G protein-coupled receptor gene, P2RY5, located at LAH3 locus, have been reported in several families with autosomal recessive hypotrichosis simplex and woolly hair. 18461368 2008